Applied Biochemistry

Scholar Year: 2020/2021

Courses

Head Teacher Responsability Maria Helena de Figueiredo Ramos Caria Head

Weekly workload Hours/week T TP P PL TC S E EL OT TPL O OT/PL Type of classes 2 2 Lectures Type Teacher Classes Hours Theoretical Totals 1 2,00 Helena Caria   2,00 Theoretical-practical Totals 1 2,00 Helena Caria   2,00

Teaching language

Portuguese

Intended learning outcomes (Knowledges, skills and competencies to be developed by the students)

It is intended that at the end of this curricualr unit the student is able to:
• Understand the molecule - metabolism and physiology relationship
• Apply the theoretical concepts in the interpretation of clinical serology values, hematology and
immunology clinical illustrating metabolic pathways deregulated in the cause of diseases

Syllabus

1. Biochemistry and life: molecular origin of life
2. Cells, tissues and systems: molecular hierarchy
3. Water and inorganic compounds
4. Buffer solutions, pH and physiologic buffers
5. Metabolism of protides
5.1. Aminocids, peptides and proteins: conformation, structure-function
5.2. Properties of enzymes: cofactors, kinetics and regulation of enzyme activity
5.3. Protein receptor
5.4. Associated pathologies
6. Metabolism of Carbohydrate:
6.1. Structure and function
6.2. ATP synthesis: glycolysis, Krebs cycle and respiratory chain
6.3. Associated pathologies
7. Metabolism of Lipids:
7.1. Biologies membranes and transport
7.2. Lipoproteins and cholesterol from the circulation
7.3. Associated pathologies
8. Metabolism of Nucleic Acids:
8.1. Flow of genetic information
8.2. Genetic code and protein synthesis
8.3. Associated pathologies
9. Metabolic Integration:
9.1. Hormones of direct and indirect action
9.2. Neurotransmitters
9.3. Associated pathologies

Demonstration of the syllabus coherence with the UC intended learning outcomes

The objectives set for the theoretical and theoretical- practical component based in the field of biochemical
concepts applied to equilibrium states and metabolic pathways associated with pathologies. The study of
chemical compounds vital to many metabolic pathways allows the knowledge of metabolic causes of
diseases of origin allows more easily to understand the physiological state. All this contents and learning
are more precise through the study of analytical data associated to specific diseases. Thus, the
programmatic contents are consistent with the objectives set.

Teaching methodologies

Expositive, demonstrative, participative and problem solving.

Demonstration of the teaching methodologies coherence with the curricular unit's intended learning outcomes

The expository-participatory methodology, adopted in the theoretical classes is well adapted to the
presentation of the several themes discussed during this curricular unit. Besides that, it allows the
participation of the students on the studied topics. Theoretical -practical classes through the resolution of
exercises allow an approach to real problems and situations with metabolic perturbations. The evaluation
methods demand that the students use the knowledge acquired during this curricular unit in an integrated
perspective. The individual assessment enables student to monitor its own knowledge.

Assessment methodologies and evidences

The unit can be effected by: (a) continuous
evaluation, ongoing at the school and that results in the exemption examination period, if the final grade is
equal to or higher than 10, and assuming the formative and summative dimensions; (b) exam, which takes
the summative dimension. The assessment is made by two written tests, each one accounting for 50% and
with 9,5 values of mínimal classification. The classification of all assessment instruments is expressed on
a scale of 0 to 20, and the weighted value of the marks obtained must be equal or greater than 10. The
exam consists in a written test, in which the approval will require a rating equal to or higher than 10.

Bibliografia

Devlin, T.M. (2006). Textbook of Biochemistry with clinical correlations, 6th Ed. York: Wiley-Liss
(Mediateca).
Kandel, E R. (1995). Essentials of neural science and behavior. Appleton & Lange.
Lozano, J.A. et al. (2003). Bioquímica Y Biologia Molecular para Ciencias de la Salud. Madrid:
Interamericana McGraw-Hill.
Quintas, A; Freire, R P; Halpern, M. (2008). Bioquímica - Organização Molecular da Vida. Lisboa: Edições
Lidel.